Background
Isabel was born in Seville around 1329, she was the youngest of three surviving children. Her elder brothers were Luis and Juan de la Cerda y Guzmán, she had five other siblings who died in childhood.
Isabel was born in Seville around 1329, she was the youngest of three surviving children. Her elder brothers were Luis and Juan de la Cerda y Guzmán, she had five other siblings who died in childhood.
The couple were married up until before 26 May 1354, when Rodrigo died. They had no children. Isabel remained unmarried for up to fourteen years, she then remarried at Seville on 15 September 1370 to Bernal de Foix, an illegitimate son of Gaston III, Count of Foix.
After the marriage, Bernal was made Count of Medinaceli.
As Isabel had a strong claim on the Castillian throne, on 25 May 1366 she was granted large estates by Henry II of Castile on the condition that she relinquish all claim to the Crown of Castile for herself and her heirs. The Medinaceli dukes had extensive estates in the Spanish provinces of Soria and Guadalajara.
Isabel and Bernal had two children:
Gaston (c 1371–1404), succeeded his father as Count of Medinaceli
Maria (died 1381), died in childhood
Isabel died after 1383 and was buried at the Monastery of Santa María de Huerta. The county of Medinaceli was later turned into a Duchy by Isabella I of Castile.
She was a member of the House de la Cerda.