Career
Isabella and Hugh III had the following children:
John II & I of Lusignan (died 1285) who succeeded him as King of Jerusalem and Cyprus
Bohemond of Lusignan (ca 1268 – Tyre, 3 November 1281, buried at the Franciscan Church of Nicosia)
Henry II of Lusignan (1271 – 31 August 1324) who succeeded John as King of Jerusalem
Amaury II of Lusignan, Prince of Tyre (died 5 June 1310), Constable of Jerusalem, who displaced Henry and became Regent of Cyprus
Mary of Lusignan (1273 – September 1322 at Tortosa and buried at Barcelona) who married by proxy at Santa Sophia, Nicosia on 15 June 1315 and in person at Girona on 27 November 1315 James II of Aragon (10 August 1267 – 2 November 1327). She died childless. Aimery of Lusignan (1274–1280 — soon before 9 April 1316), succeeded Guy as Constable of Cyprus in 1303, briefly succeeded Amalric as Regent of Cyprus and Governor of Cyprus on 6 June 1310
Guy of Lusignan (1275–1280 – 1303, probably buried at Nicosia), Constable of Cyprus ca. 1291, married on 7 December 1291 Eschive d"Ibelin, Lady of Beirut (1253–1312), parents of:
Hugh IV of Lusignan, King of Cyprus
Isabella of Lusignan (1296–1300 – after 1340), married on 21 July 1322 Eudes de Dampierre, Titular Constable of Jerusalem (died 1330)
Margaret of Lusignan (ca 1276 – in Armenia, 1296), who married 9 January 1288 Thoros III of Armenia
Alice of Lusignan (1277–1280 – after March 1324), married 1292–1295 or ca.
1292/1294 Balian of Ibelin (died 1315/1316 in Kerynia, soon before 19 April 1316), Titular Prince of Galilee and Bethlehem
Helvis de Lusignan (died after March 1324)
Isabella of Lusignan (ca 1280 – 1319), married firstly in 1285/1290 Constantine of Neghir, Lord of Partzerpert (died 1308), and secondly ca.
1310 King Oshin of Armenia, who divorced her before or in 1316.