Career
Isa started playing football at PFC Svetkavitsa"s youth teams. Levski Sofia
Ismail Isa made his unofficial debut for Levski in a friendly match against Dynamo Kyiv on 20 January 2008. He played for 33 minutes.
The result was a 1–2 loss for Levski.
On 20 February, he scored his first goals in a friendly against Vidima-Rakovski Sevlievo. He scored two goals in the 75th and 85th minute.
He made his official debut in a 1–0 defeat away to Lokomotiv Plovdiv. During 08/09 season, he was loaned to OFC Sliven 2000.
Anyway, after the end of the season, he returned to Levski.
Isa re-debuted for Levski on 15 July 2009 in the 2nd Qualifying round of Union of European Football Associations Champions League, where Levski defeated the team of UE Sant Julià. His return was in a match against Dundalk – a second qualifying round of Europa League. Isa scored two of the goals.
Isa scored his first goal for Levski in the Bulgarian A Professional Football Group on 23 August 2010 against Kaliakra Kavarna.
= Lokomotiv Mezdra (loan) On 2 August 2009 Ismail Isa was loaned for half a season in Lokomotiv Mezdra. After matches, in which he scored 7 goals in 12 matches, Isa returned to Levski.
Shortly afterwards on 11 January 2010, though, he was loaned out to Lokomotiv Mezdra again. On 21 March 2010, he scored the only goal for his side to give the team from Mezdra a 1:0 lead against the other Bulgarian top team CSKA Sofia.
This goal got him in the news since just a few minutes after it the CSKA supporters flooded the field and stopped the match, earning their team a 3–0 disciplinary loss (4:0 aggregate loss).
After scoring 11 goals in 25 caps Isa was brought back to Levski on 24 May.
Karabükspor
In June 2011, Isa joined Turkish Super League club Karabükspor. Media reports estimated the transfer fee to be around €200,000. Litex Lovech
Isa was signed by Litex Lovech for the 2012/2013 season and netted 7 goals in 11 appearances during the first half of the season.
He finished the 2012/2013 A PFG season as the fifth highest goal scorer in the league, having managed 11 goals.
Sheriff Tiraspol
In June 2013, Isa signed a contract with Moldovan club Sheriff Tiraspol. Isa was a part of Bulgaria national under-19 football team
With the team he plays on 2008 Union of European Football Associations European Under-19 Football Championship in Czechoslovakian Republic. On 29 April he scored a goal in qualifying match against Norway.
On 7 February 2015, Isa made his first appearance for Bulgaria, in the 0:0 draw with Romania in a non-official friendly match, playing over the course of the first 70 minutes.
His father is of Turkish descent and his mother is of Bulgarian descent. Levski Sofia
Bulgarian A Football Group (1) - 2008-2009
Bulgarian Supercup (1) - 2009
Football Club Sheriff Tiraspol
Moldovan Super Cup (1) - 2013
Moldovan National Division: 2013-2014.