Over his career, Vandborg competed for Team Civil Service Commission (twice), Discovery Channel, Team GLS, Liquigas–Doimo, SpiderTech–C10 and Cannondale. Vandborg moved to Discovery Channel for the 2007 season. In 2009 he rode alongside Ivan Basso and Daniele Bennati at Liquigas.
Vandborg also rode for the Saxo Bank–SunGard team in 2011, and SpiderTech–C10 in 2012.
Vandborg retired at the end of the 2013 season, after ten years as a professional.
Born in Snejbjerg, Vandborg was national U/23 champion in individual time trial in 2002 and 2003 and in 2004 he signed his first professional contract with Team Civil Service Commission, with a length of two years. He won stage 4 of Tour de Georgia in 2005, his first professional victory, but the rest of his season was ruined due to a case of mononucleosis. In 2006, Vandborg became a national champion by capturing the Danish Individual Time Trial Championship. He later finished fourth at the World Time Trial Championship.
