Career
Her first marriage was to the sebastokratōr Isaac Komnenos, a great-nephew of the emperor Manuel I Komnenos. They had one daughter, Theodora Angelina. Soon after Anna"s father became emperor, in 1195, Isaac Komnenos was dispatched to combat the Vlach-Bulgarian Rebellion.
He was captured, became a pawn between rival Bulgarian and Vlach factions, and died in chains.
Her second marriage to Theodore Laskaris, eventually emperor of Nicaea, was celebrated in a double wedding in early 1200 (the other couple was Anna"s sister Irene and Alexios Palaiologos). Nicholas Laskaris (died c 1212)
John Laskaris (died c 1212)
Irene Doukaina Komnene Laskarina, who married first the general Andronikos Palaiologos and then John III Doukas Vatatzes
Maria Laskarina, who married King Béla IV of Hungary.