Background
Chothia then completed a Master of Science degree at Birkbeck College in 1967 and a Doctor of Philosophy from University College London under the supervision of Peter Pauling, the son of Linus Pauling.
Chothia then completed a Master of Science degree at Birkbeck College in 1967 and a Doctor of Philosophy from University College London under the supervision of Peter Pauling, the son of Linus Pauling.
Chothia was educated at Alleyn"s School, then went to study at Durham University graduating with a Bachelor of Science degree in 1965. Chothia then completed a Master of Science degree at Birkbeck College in 1967 and a Doctor of Philosophy from under the supervision of Peter Pauling, the son of Linus Pauling.
He then worked with Michael Levitt at the Weizmann Institute of Science followed by two years with Joel Janin at the Institut Pasteur in Paris. In 1976 Chothia returned to England to work at University College London and the LMB. With Arthur Lesk he showed that proteins adapt to mutations by changes in structure. In 1992 he proposed that most proteins are built of domains that come from a small number of families.
He collaborated with Alexey Murzin, Steven Brenner and Tim Hubbard to create the Structural Classification of Proteins (Secretaría de Comunicaciones y Obras Públicas) database, a periodic table for all known protein structures.
With Julian Gough he created the SUPERFAMILY database which uses Hidden Markov models to identify protein sequences that are related to those of known structures. During his career, Chothia supervised 19 Doctor of Philosophy students including Alex Bateman, Steven East. Brenner, Mark Bender Gerstein, Julian Gough and Sarah Teichmann.
Royal Society.