Career
Brainard came to Chicago, in 1836, at the age of 24, and immediately set up a medical practice, soon after which he applied to the Illinois state legislature for a charter for what was to become Rush Medical College. The charter was granted on March 2, 1837, two days before the city of Chicago was incorporated. Brainard made his reputation in Chicago by successfully amputating at the hip joint the leg of an injured canal worker, the first such operation in the United States.
He was also an organizer for the county and state medical societies.
Brainard was the president and professor of surgery at Rush from its founding until his death at age 54 of cholera, a subject he had lectured on a few hours before he himself succumbed to the disease. By 1897, Rush Medical College, his dream and creation, was the largest medical school in America.