Career
He was one of the sons of Pedro de Zuñiga y Manrique de Lara, 3rd Count of Plasencia. His mother,Teresa de Guzman y de Guzman, daughter of Juan Alonso Perez de Guzman y Orozco, died in 1458. Then, Antonio became thus the step son of Isabel de Zuñiga y Pimentel.
In 1519, Antonio took part in the diplomatic meetings headed by Mercurino Gattinara at Montpellier, France, with king Francis I of France representatives.
In 1521 Antonio was general of the Royal Army who carried out military actions against the rebellious groups at Torrelobaton, Villalar and Toledo during the One of the results was that the Bishop of Zamora, Antonio de Acuña, was executed near Simancas.
