Background
Savageau, Michael Antonio was born on December 3, 1940 in Fargo, North Dakota, United States. Son of Antonio Daniel and Jennie Ethelwin (Kaushagen) Savageau.
(The reductionist approach of molecular biology has given ...)
The reductionist approach of molecular biology has given us detailed descriptions for many biochemical constituents of complex biological systems. For some of the simpler systems nearly the entire "parts catalog" has been assembled. These developments have set the stage for a new generation of questions -- questions of integration that deal with the relation between behavior of intact systems and their underlying molecular determinants, questions of unifying design principles that will give meaning to the bewildering diversity of alternative molecular designs, questions of higher-level theory and quantitative prediction, which currently are not available in most of biology. The motivation to develop this new perspective comes from the study of complex biochemical pathways, intricate circuits of gene regulation, network interactions within the immune system, plasticity of neural networks, and pattern formation by cellular networks. All these networks consist of more elemental constituents that find their meaning within the context of the intact system. The integrative perspective requires a new language and methodology. The objective of this text is to systematically develop these and to apply them to specific classes of metabolic networks and gene circuitry. The applications demonstrate the power of this approach to formulate and answer fundamental questions concerning network function, design and evolution that currently cannot be addressed by other methods. The text was first published in 1976 and is being reissued to commemorate the 40th anniversary of the author's first paper published on Biochemical Systems Analysis.
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science educator engineering educator
Savageau, Michael Antonio was born on December 3, 1940 in Fargo, North Dakota, United States. Son of Antonio Daniel and Jennie Ethelwin (Kaushagen) Savageau.
Bachelor of Science, University Minnesota, 1962; Master of Sciences, University Iowa, 1963; Doctor of Philosophy, Stanford University, 1967; postgraduate, Stanford University, 1968-1970; postgraduate, University of California at Los Angeles, 1967-1968.
Research fellow University of California at Los Angeles, 1967-1968. Lecturer Stanford University, California, 1968-1969. From assistant to full professor University Michigan, Ann Arbor, 1970—1978, professor microbiology and immunology, 1978—2003, chairman department, 1982—1985, 1992—2003, professor chemical engineering, director cellular biotechnology laboratories, 1988—1991, director National Institutes of Health training program in cellular biotechnology, 1991—1992, director bioinformatics program, 1998—2001, Nicolas Rashevsky distinguished university professor, 2002—2003, Nicolas Rashevsky distinguished university professor emeritus, since 2003.
Moore distinguished scholar California Institute of Technology, 2003. Distinguished professor biomedical engineering University California, Davis, since 2003, chairman department, since 2005. Consultant Upjohn Company, Kalamazoo, 1979—1981, National Institutes of Health, Bethesda, Maryland, 1981—1982, 1994—1995, 1997—2000, 2005, Synergen, Boulder, Colorado, 1985—1987, National Research Council/Howard Hughes Medical Institute, 1997—2001, National Science Foundation, since 1999, National Academy of Sciences, since 2001, Swedish Foundation for Strategic Research, Stockholm, 2001—2002.
Senior research fellow Max Planck Institute, Gottingen, Germany, 1976—1977. Fellow Australian National University, Canberra, Australia, 1983—1984. Lecturer CIGENE Center for Integrated Genetics, Agricultural University Norway, Aas, since 2001.
Visiting professor department biochemistry University Arizona, Tucson, 1994. Visiting professor Institut des Hautes Etudes Scientifiques, Bures-Sur-Yvette, France, 2002.
(The reductionist approach of molecular biology has given ...)
Fellow: American Association for the Advancement of Science. Member: Institute of Electrical and Electronics Engineers (senior ), biomedical Engineering Society, Institute Medicine of National Academy of Sciences (lecturer found for microbiology 1993-1995, lecturer American Mathematics Society Josiah Willard Gibbs 2006), International Federation Nonlinear Analysts (board directors since 1997), Society Mathematics Biology 1987-1990, Society General Physiologists, Biophysics Society, Society Industrial and Applied Mathematics, American Society Microbiology, American Chemical Society.
Married Ann Elisa Birky, July 22, 1967. Children– Mark Edward, Patrick Daniel, Elisa Marie.