Doctor of Medicine, University Freiburg, Germany, 1960.
Scientific assistant Universität Würzburg, Germany, 1963-1968, lecturer pathology Germany, 1968-1973. Professor pathology University Heidelberg, Germany, since 1973. Head division cell pathology German Cancer Research Center, Heidelberg, 1973-1999, chairman science council, 1981-1984, 87-88, trustee, 1996-1999.
Guest professor University Xi'an, China, 2000. Chairman Alumni DKFZ, Heidelberg, 2002-2010. Visiting professor University Wuhan, China, 2005.
Member of Society for Histochemistry, Society for Toxicol. Pathology, American Association for Cancer Research, German Society for Cancer, German Society for Cell Biology, German Society for Pathology, European Association Pathology, European Association Cancer Research (president 1987-1993).
Married Helga Wende; children: Christophr, Bettina, Daniel.