Background
Lawrence, Peter Anthony was born on June 23, 1941 in Longbridge, Lancashire, United Kingdom. Son of Ivor Douglas and Joy Frances (Liebert) Lawrence.
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book
The Making of a Fly: The Genetics of Animal Design
(Understanding how a multicelluar animal develops from a s...)
Understanding how a multicelluar animal develops from a single cell (the fertilized egg) poses one of the greatest challenges in biology today. Development from egg to adult involves the sequential expression of virtually the whole of an organisms genetic instructions both in the mother as she lays down developmental cues in the egg, and in the embryo itself. Most of our present information on the role of genes in development comes from the invertebrate fruit fly, Drosophila. The two authors of this text (amongst the foremost authorities in the world) follow the developmental process from fertilization through the primitive structural development of the body plan of the fly after cleavage into the differentiation of the variety of tissues, organ and body parts that together define the fly. The developmental processes are fully explained throughout the text in the modern language of molecular biology and genetics. This text represents the vital synthesis of the subject that many have been waiting for and it will enable many specific courses in developmental biology and molecular genetics to be focussed upon it appealing to 2nd and 3rd year students in these disciplines as well as in biochemistry, neurobiology and zoology. It will also have widespread appeal amongst researchers.
http://www.amazon.com/gp/product/0632030488/?tag=2022091-20
- The Making of a Fly: The Genetics of Animal Design by Peter A. Lawrence (1992-04-15) (Will be shipped from US. Used books may not include compa...)
Peter Anthony Lawrence
Edit ProfileEducation
Bachelor, Cambridge University, United Kingdom, 1962. Doctor of Philosophy, Cambridge University, United Kingdom, 1965.
Career
He was a staff scientist of the Medical Research Council from 1969 to 2006. Lawrence"s main discoveries lie in trying to understand what type of information is required to shape an animal and generate a pattern (such as on a butterfly wing or a fingerprint). He is the principal advocate of the idea that cells in a gradient of a morphogen develop according to their local concentration of the morphogen and that this mechanism is used to generate patterns of cells.
Together with Ginés Morata, he has helped establish the compartment theory first proposed by Antonio Garcia-Bellido.
In this hypothesis, a set of cells collectively builds a territory (or "compartment"), and only that territory, in the animal. As development proceeds, a "selector gene" switches on in a subset of this clone of cells, and the clone becomes divided into two sets of cells that construct two adjacent compartments.
Much of the evidence for the theory comes from studies on the Drosophila fly wing. Foreign the last twenty years he has been working, in collaboration with Gary Struhl on the development of the adult abdomen of Drosophila, with the aim of understanding the design and construction of the epidermal patterns, particularly planar polarity and cell affinity.
Achievements
Works
book
-
The Making of a Fly: The Genetics of Animal Design
(Understanding how a multicelluar animal develops from a s...)
-
The Making of a Fly: The Genetics of Animal Design by Peter A. Lawrence (1992-04-15)
(Will be shipped from US. Used books may not include compa...)
-
The Making of a Fly: The Genetics of Animal Design
Membership
Royal Society; Royal Swedish Academy of Sciences.
Interests
Connections
Married Ruth Birgitta Haraldson, July 9, 1971.
