Educated at Lobamba National School and Zombode Primary School, he completed his secondary education at Matsapa Swazi National High School.
After entering government service Prince Masitsela spent two years at the Court of Appeal and then joined the postal services where he successfully challenged the segregation practices which had been inherited from the system in South Africa. In 1960 he was appointed Clerk to the Swazi Higher Court of Appeal. Three years later he became labour affairs adviser to the King-in-Council.
Prince Masitsela made his mark in politics by coming top of the poll in his constituency at the elections in June 1964.
He travelled to London in 1964 to represent the Legislative Council at the meeting of the Commonwealth Parliamentary Association. After winning his seat in the 1967 election he was appointed Assistant Minister of Labour in the Deputy Prime Minister’s office. He achieved cabinet rank after the May 1972 elections when he became Minister of Local Administration.
Son of King Sobhuza II, painter and poet with a sense of natural rebellion against all forms of racial discrimination. Keenly interested in labour relations, the Prince has been a vigorous advocate of a code of conduct which would eliminate any hint of second-class citizenship and would ensure fair treatment for all.