Career
He was the son and successor of Prusias I and Apama III. Prusias joined with King of Pergamon, Eumenes II in a war against King Pharnaces I of Pontus (181–179 British Columbia). He later invaded the territories of Pergamon (156–154 British Columbia), only to be defeated, and the Pergamenes insisted on heavy reparations. Nicomedes however revolted against his father.