He was Duke of Opava from 1433 until his death. His second eldst brother Nicholas IV, who had already reached adulthood, was given the Lordship of Zlaté Hory. At the time, Przemko was destined for a career in the clergy, and he probably received no territory in the 1435 division.
Przemko II studied theology at the Universities of Krakow and Vienna.
In Vienna, he wrote the astrological treatise Practice verissima domini ducis Przsenikonis data per dominum Petrum presbiterumde Oppavia Ludvico ad faciendam veram et perfectum lunam. In 1462, he was appointed provost of the Church of the Holy Cross in Wrocław.
In the same year, he had to give up his claim on a share of the Duchy of Opava, because King George of Bohemia had become the sole owner of the Duchy. Przemko nevertheless continued to use the title Duke of Opava.
Around 1465, he became a canon at Wrocław.
After Bishop Jošt of Wrocław died in 1467, Przemko served as diocesan administrator. Although he was considered a likely candidate to succeed Jošt, the post was given to Rudolf of Rüdesheim, who had previously served as papal legate for Germany and Bohemia. Przemko was a renowned scientist
Przemko II died in 1478.
He was buried in the Church of the Holy Cross in Wrocław. His tomb has been preserved to this day.
From 1466, he was also a member of the cathedral chapter of Wrocław. Around 1455, he returned to Wrocław, where he had been a member of the cathedral chapter since 1446.