Background
Radulescu, Razvan Tudor was born on March 5, 1966 in Cluj, Romania. Son of Vifor and Sanda Radulescu. arrived in Germany, 1978.
Radulescu, Razvan Tudor was born on March 5, 1966 in Cluj, Romania. Son of Vifor and Sanda Radulescu. arrived in Germany, 1978.
high school education at Wilhelm Hittorf Gymnasium, Muenster, Germany, 1978-1985 (final grade: 1.0);
medical studies at Westfaelische Wilhelms Universitaet Muenster, Germany, 1985-1992;
visiting medical student, departments of neurosurgery and anaesthesia, University of Oxford, England, 1988;
pre-doctoral student, University of Alabama at Birmingham, USA, 1989-1990;
doctor of medicine (Dr.med./M.D.), Westfaelische Wilhelms Universitaet Muenster, Germany, 1992;
associate professor of experimental pharmacology, Ludwig Maximilians Universitaet Munich, Germany, 2002.
surgical subintern, Centre Hospitalier Princesse Grace, Monaco, 1991;
medical subintern, Harvard Medical School, Boston, 1991;
founder and coordinator, Molecular Concepts Research (MCR), Munich/Muenster, since 1992;
senior resident, department of medicine, Klinikum Grosshadern, Munich, 1995-1997;
medical researcher, Walther Straub Institute of Pharmacology and Toxicology, Munich, 1999-2003.
Achievements include
a) discovery of an amino acid sequence in insulin predicting a complex formation between insulin and the retinoblastoma tumor suppressor protein (RB);
b) identification of nuclear localization signals in insulin-like growth factor binding proteins 3 and 5 as well as in the insulin receptor;
c) proposal of the nucleocrine pathway in hormone/growth factor action, particularly with regard to insulin and the insulin-like growth factors 1 and 2, implying that hormones/growth factors and/or their receptors are viral oncoprotein-like molecules which move into the cell nucleus where they influence growth by interacting with tumor suppressor proteins, e.g. during embryogenesis and oncogenesis;
d) revealing a putative NADH-binding site and a ribonucleoprotein A1-like domain in the prion protein, thus suggesting that the infectious prion particles implicated in causing neurodegenerative disorders such as the Creutzfeldt-Jakob disease or mad cow disease are likely to bind and contain nucleic acids due to above structural properties of the prion protein;
e) discovery of zinc finger-like motifs in antibody constant regions, pointing to the possibility that these antibody domains may physically associate with DNA/ribonucleic acid and thus directly affect their own production, e.g. during an immune response;
f) developing the concept on insulin-degrading enzyme (IDE) being a potential tumor suppressor protein that protects RB from being inactivated by insulin;
g) deriving from RB anti-cancer peptides (MCR peptides) that have proven to be effective against human tumor cells in vitro and in vivo.
Avocations: literature, music, basketball, tennis, chess.
