Doctor rerum naturalium, Humboldt-University, 1961.
Scientific assistant, resident, Ernst-Moritz-Arndt-University, Greifswald, 1958-1960; postdoctoral, Humboldt-University, Berlin, 1961-1974; senior assistant, Humboldt-University, Berlin, 1974-1976; head of department, Humboldt-University, Berlin, 1976-1988; director, Institute of Medical Genetics, Humboldt Medical School, Berlin, since 1988.
Fellow Royal Society Medicine. Member New York Academy of Sciences, Hungarian Society Human Genetics.
Daughter of Erhard Alexander and Käthe (Lang) Kasten. Divorced; children: Susanne, Katharina.