Background
lieutenant was Manuel who suggested the marriage of his daughter Maria the Porphyrogenita to a son of William V. Since Conrad and Boniface were already married, and Frederick was in the priesthood, the only eligible son was the youngest, 17-year-old Renier.
Career
The Byzantine chronicler Niketas Choniates described him as handsome, blond (his hair "shone like the sun") and beardless. Renier arrived in Constantinople in autumn 1179 and soon afterwards accompanied Manuel on a military expedition. The wedding was celebrated with lavish festivity including games in the Hippodrome of Constantinople, as fully described by the Latin Patriarch of Jerusalem, William of Tyre, who happened to be present.
Renier was given the title Caesar, was renamed John, and (according to some Western sources) was granted Thessalonica, presumably as an estate for life, a pronoia.
Maria was second in line to the throne, and had only been deprived of the succession by the birth of her much younger half-brother Alexios. Thus Renier became entangled in the perpetual power struggle around the Byzantine throne.
With the death of Manuel in September 1180, the throne fell to the boy Alexios II, with his mother, the empress dowager Maria, acting as regent. The Empress caused a scandal by taking the protosebastos Alexios Komnenos as a lover.
This, combined with her Latin-friendly views, triggered a plot to end the regency (or, as some describe it, to overthrow the Emperor) and give power to Maria and Renier.
The plot was discovered, and several conspirators arrested. Fighting ensued, later dubbed the Holy War as it took place in that most holy church. Eventually, the conspirators were offered an amnesty to end the hostilities.
Andronikos" takeover was marked by the massacre of the Latin population that followed.
Maria died soon afterwards, allegedly by poison: she was, no doubt, a potential focus of opposition to the usurper. Renier seems to have shared her fate, though his death is noted by very few sources.
Alexios II was forced to recognise Andronikos as his co-Emperor, and was later murdered. The Latin massacre had not been forgotten, twenty years later, when the leaders of the Fourth Crusade found reasons to divert their expedition to Constantinople.
Later sources suggest that Renier"s surviving older brother Boniface based his claim to Thessalonica on his late brother"s title.