Background
Pryse was the son of Sir Richard Pryse, 1st Baronet of Gogerddan, Cardiganshire and his first wife Hester, daughter of Sir Hugh Myddelton, 1st Baronet.
Pryse was the son of Sir Richard Pryse, 1st Baronet of Gogerddan, Cardiganshire and his first wife Hester, daughter of Sir Hugh Myddelton, 1st Baronet.
He succeeded his father in the baronetcy in around 1651. He served as a Justice of the Peace for Cardiganshire from 1652 to his death and was appointed High Sheriff of Cardiganshire for 1656-1657.
In 1660, he was elected Member of Parliament for Cardiganshire in the Convention Parliament.