In 1682, he was commissioned as Major of the Goose Creek Men. By 1691, he was commissioned as a colonel for King William. In 1702 Daniell led forces in James Moore"s expedition to Saint Augustine, which unsuccessfully besieged the Castillo de San Marcos.
He later also led provincial forces in the 1711 Tuscarora War and the 1715 Yamasee War.
Daniell is best known for being governor of the British Province of North Carolina from 1703-1705, and governor of the British Province of South Carolina from 1716-1717. Daniel Island in Charleston, of which he was an early owner, is named for him.