Background
Lundblad, Roger Lauren was born on October 31, 1939 in San Francisco, California, United States. Son of Lauren Alfred and Doris Ruth (Peterson) Lundblad.
(Chemical Reagents for Protein Modification, 2nd Edition p...)
Chemical Reagents for Protein Modification, 2nd Edition provides a unique combination of theoretical and practical considerations for the use of chemical reagents for site-specific modification of proteins. The book is divided into three sections, with the first section describing general techniques, including information on the organic chemistry of the various modification reactions; the separation and characterization of site-specific modified proteins, including applications to proteins separated by electrophoresis followed by blotting; the specific chemical cleavage of peptide bonds in proteins; the separation of peptides by high-performance liquid chromatography and electrophoresis; and the use of chemical reagents to assess conformational change in proteins. The second section provides an encyclopedic description of reagents and reactions for the site-specific modification of individual amino acid residues in proteins. The final section presents descriptions of the use of chemical reagents to label biologically significant sites in proteins, including enzyme active sites and the use of covalent cross-linking to measure protein-protein interactions. Particular emphasis is placed on the use of photoaffinity reagents. The book will be an extremely useful research tool for all investigators interested in the solution chemistry of proteins.
http://www.amazon.com/gp/product/0849350867/?tag=2022091-20
( The activity of many biopharmaceutical polymers is depe...)
The activity of many biopharmaceutical polymers is dependent on conformation, and the next several years will see increased interest in the conformational analysis of these polymers resulting from the development of biosimilar or "follow-on" biological products. While a wide variety of approaches to analysis exists, finding the most viable ones would be much easier with a consolidated reference that details the benefits and cost of each approach, with an emphasis on real results and real products. Explores the Growing Role of Conformational Analysis in Comparing Generic Biopharmaceuticals Approaches to the Conformational Analysis of Biopharmaceuticals gathers the most useful techniques and methods into a single volume, putting the greatest emphasis on those approaches that have proven the most fruitful. Rather than cover specific uses of techniques in detail, this book provides commercial biotechnologists and researchers with the information and references they need to make good choices about the technology they choose to use. With a large number of references that direct readers to primary source material, it includes studies drawn from the gamut of current literature, covering physical methods, such as differential scanning calorimetry, light scanning, and analytical ultracentrifugation. It also addresses chemical methods, such as hydrogen–deuterium exchange and trace labeling, along with infrared, ultraviolet, and Raman spectroscopy. Written by Roger Lundblad, a true pioneer in protein science, this volume supplies the necessary information researchers need to access when deciding on the most cost-effective approach, including: • Comparability of biopharmaceuticals • Characterization of follow-on biologics • Quality attributes of protein biopharmaceuticals • Confrontational analysis of biopharmaceutical products With a clear focus on relevant commercial biotechnology, this book belongs on the shelves of those serious researchers who are paving the way for the next generation of biopharmaceutical polymers.
http://www.amazon.com/gp/product/1439807809/?tag=2022091-20
(Chemical Reagents for Protein Modification, 2nd Edition p...)
Chemical Reagents for Protein Modification, 2nd Edition provides a unique combination of theoretical and practical considerations for the use of chemical reagents for site-specific modification of proteins. The book is divided into three sections, with the first section describing general techniques, including information on the organic chemistry of the various modification reactions; the separation and characterization of site-specific modified proteins, including applications to proteins separated by electrophoresis followed by blotting; the specific chemical cleavage of peptide bonds in proteins; the separation of peptides by high-performance liquid chromatography and electrophoresis; and the use of chemical reagents to assess conformational change in proteins. The second section provides an encyclopedic description of reagents and reactions for the site-specific modification of individual amino acid residues in proteins. The final section presents descriptions of the use of chemical reagents to label biologically significant sites in proteins, including enzyme active sites and the use of covalent cross-linking to measure protein-protein interactions. Particular emphasis is placed on the use of photoaffinity reagents. The book will be an extremely useful research tool for all investigators interested in the solution chemistry of proteins.
http://www.amazon.com/gp/product/0849350875/?tag=2022091-20
(Chemical Reagents for Protein Modification, 2nd Edition p...)
Chemical Reagents for Protein Modification, 2nd Edition provides a unique combination of theoretical and practical considerations for the use of chemical reagents for site-specific modification of proteins. The book is divided into three sections, with the first section describing general techniques, including information on the organic chemistry of the various modification reactions; the separation and characterization of site-specific modified proteins, including applications to proteins separated by electrophoresis followed by blotting; the specific chemical cleavage of peptide bonds in proteins; the separation of peptides by high-performance liquid chromatography and electrophoresis; and the use of chemical reagents to assess conformational change in proteins. The second section provides an encyclopedic description of reagents and reactions for the site-specific modification of individual amino acid residues in proteins. The final section presents descriptions of the use of chemical reagents to label biologically significant sites in proteins, including enzyme active sites and the use of covalent cross-linking to measure protein-protein interactions. Particular emphasis is placed on the use of photoaffinity reagents. The book will be an extremely useful research tool for all investigators interested in the solution chemistry of proteins.
http://www.amazon.com/gp/product/0849350972/?tag=2022091-20
(Revised and updated, Chemical Reagents for Protein Modifi...)
Revised and updated, Chemical Reagents for Protein Modification, Third Edition is an encyclopedic work describing the many approaches to the site-specific modification of proteins. More than 2,000 references are cited describing the development of the various reagents. This book explores how the use of site-specific protein modification relates to a wide variety of biotechnology processes and products, such as protein microarrays, hydrogels, controlled-release pharmaceuticals, and biotherapeutics, and proteomics. With chapters focusing on analyses of individual amino acids, additional chapters cover chemical cross-linking and the chemical cleavage of peptide chains. There is considerable reference to the use of site-specific chemical modification in proteomics. The author pays particular attention to the general environmental factors that influence the reactivity of individual amino acid residues. He presents techniques for the characterization of modified proteins, including mass spectrometry, and includes increased coverage of spectroscopic techniques and crystallographic analyses. This is followed by coverage of nitrosylation reactions and other non-enzymatic modification processes. Specific reference is given to the differential labeling of protein functional groups with reagents labeled with stable isotopes. Resources include a list of current journals that publish site-specific chemical modification studies, the most commonly used reagents and their properties, and a contact list of reagent suppliers. Chemical Reagents for Protein Modification, 3rd Edition presents the most frequently used methods for the site-specific chemical modification of proteins, techniques for protein characterization, precise laboratory data for factors that influence reactivity and reproducibility, and industry-specific resources.
http://www.amazon.com/gp/product/0849319838/?tag=2022091-20
(Largely driven by major improvements in the analytical ca...)
Largely driven by major improvements in the analytical capability of mass spectrometry, proteomics is being applied to broader areas of experimental biology, ranging from oncology research to plant biology to environmental health. However, while it has already eclipsed solution protein chemistry as a discipline, it is still essentially an extension of classical protein chemistry, owing much of its maturation to prior contributions. Unfortunately, this debt is not always evident in current literature. The Evolution from Protein Chemistry to Proteomics: Basic Science to Clinical Application, in providing a different perspective than other reviews, strengthens the connection between solution protein chemistry and proteomic technology. Towards this end, Roger Lundblad, a long-time leader in protein chemistry and a scientist who has worked in both academics and industry, brings together some seemingly disparate areas into a single volume. Discussing analytical proteomics, expression proteomics, and clinical proteomics (biomarker identification), he provides coverage that is uniquely rich in detail. Lundblad applies this detail to sample preparation for proteomic analysis, including preparation from blood and tissues. He also presents specifics on the prefractionation of samples used to identify specific subproteomes such as phosphoproteomes and glycoproteomes. Comprehensive reviews are provided covering the chemical modification of proteins, including its use for chemical proteomics. Special attention is given to challenges that impede the identification, validation, and development of biomarkers into clinically useful diagnostic analytes. A bestselling author, Lundblad utilizes classical protein chemistry literature in providing an intellectual basis for proteomics that merges current concepts with the existing literature, while providing the technical detail necessary for the effective commercialization of proteomics.
http://www.amazon.com/gp/product/0849396786/?tag=2022091-20
(While biomedical investigation has greatly advanced, inve...)
While biomedical investigation has greatly advanced, investigators have lost touch with and inadvertently corrupted significant nomenclature at the foundation of their science. Nowadays, one has to be an insider to even understand the titles of journals, as modern biochemists have a tendency to invent new terms to describe old phenomena and apply acronyms in a haphazard way. In addition, while the use of kits now saves time, by taking shortcuts, many have lost touch with the principles that lie behind the processes they employ. Assembled by Roger Lundblad, the Biochemistry and Molecular Biology Compendium provides both academic and industrial researchers with an exceptionally accessible resource that offers a plethora of practical information not found in more database-oriented resources. A renowned scientist and author who bridges the old school of protein research and current proteomics, Dr. Lundblad is uniquely qualified to bring forth this handy resource. With great respect for the roots of the science, Dr. Lundblad provides a list of commonly used acronyms with definitions, as well as a glossary of terms and subjects used in biochemistry, molecular biology, biotechnology, proteomics, genomics, and systems biology. He also provides a chapter on those chemicals commonly employed in biochemistry and molecular biology, complete with properties and structure drawings, as well as a detailed accounting of protease inhibitors and protease inhibitor cocktails. A list of organic name reactions used in biochemistry is also included, as is a list of buffers with references to specific uses and unwanted side reactions. Until now, this information could only be garnered from older books and Internet searches convoluted by uncertain nomenclature. Biochemistry and Molecular Biology Compendium may not provide all the answers, but researchers will find it to be a valuable tool that will save them time, as well as provide essential links to the roots of their science.
http://www.amazon.com/gp/product/1420043471/?tag=2022091-20
(This exciting laboratory support book encompasses the enc...)
This exciting laboratory support book encompasses the encyclopedic coverage of the most frequently used methods for the site-specific chemical modification of proteins. In a concise manner, it presents methods for the characterization of modified proteins, including: • amino acid analysis • protein sequence analysis • chemical cleavage of protein chains • chromatographic separation of peptides It also discusses various approaches to the determination of solution protein concentration. It includes a complete literature survey of the various reagents, a list of the most commonly used reagents with their physical and chemical properties, and a list of preferred reagent suppliers.
http://www.amazon.com/gp/product/0849326060/?tag=2022091-20
( Reflecting the versatility of the author’s science and ...)
Reflecting the versatility of the author’s science and the depth of his experience, Application of Solution Protein Chemistry to Biotechnology explores key contributions that protein scientists can make in the development of products that are both important and commercially viable, and provides them with tools and information required for successful participation. One of the of the world’s most respected protein researchers, Roger Lundblad does not succumb to the notion that new is always better. The application of protein science to the practice of commercial biotechnology is traced to the underlying basic solution protein chemistry. It is only by achieving this understanding that the full potential of protein science may be obtained in the development and characterization of the diverse products of modern biotechnology. Dr. Lundblad also goes far beyond the biopharmaceutical applications that are often equated with protein science today to demonstrate the field’s unique versatility. From the making of bread and the invention of adhesives to the production of pharmaceuticals and the development of recombinant DNA products— in each of these products, the role of the protein chemist remains prominent. The important point is that classical protein chemistry is a critical part of the practice of biotechnology in the marketplace. Providing the direction and the foundational work needed by students as well as the details and hundreds of references needed by designers and developers, this remarkable work— • Delves into the application of protein science for producing products as diverse as adhesives, drug delivery systems, and quality food products • Explores chemistry of attachment of proteins and peptides to solid surfaces with regard to applications both for the improvement of steel and titanium and in DNA and protein microarrays • Describes the development of bioconjugates used in antibodies • Offers essential advice on guidelines required for producing licensed biopharmaceutical products While he does include a great deal of material not found in other sources, Dr. Lundblad makes a point to separate what is truly new from that which has merely been renamed. A reference unlike most, scientists and students eager to learn will find a text that is as practical as it is purposeful.
http://www.amazon.com/gp/product/1420073419/?tag=2022091-20
( The use of the chemical modification of proteins has ev...)
The use of the chemical modification of proteins has evolved over the past 80 years, benefiting from advances in analytical, physical, and organic chemistry. Over the past 30 years, the use of chemical reagents to modify proteins has been crucial in determining the function and structure of purified proteins. This groundbreaking work is part of the foundation of emerging disciplines of proteomics, chemical biology, structure biology, and chemical proteomics. Chemical Reagents for Protein Modification, Fourth Edition provides a comprehensive review of reagents used for the chemical modification of proteins, representing a major revision of the work presented in previous editions. The completely updated Fourth Edition is substantially larger and includes five new chapters: • Alkylating Agents • Acylating Agents • Nitration and Nitrosylation • Oxidation • Modification of Proteins with Reducing Agents There is greatly increased coverage of the chemical modification of cysteine, which is critical for bioconjugate synthesis. The chapter on reduction also provides information necessary for bioconjugate synthesis as well as for the processing of inclusion bodies. The book places emphasis on conditions that affect the specificity of the chemical modification of proteins, such as solvent and temperature. The format has been markedly revised, presenting information based on the chemical nature of the modifying material and on the amino acid residue modified. This new version has increased significance to biopharmaceuticals. Much of the information is in tabular form, which enables the rapid location of cited material.
http://www.amazon.com/gp/product/146657190X/?tag=2022091-20
Lundblad, Roger Lauren was born on October 31, 1939 in San Francisco, California, United States. Son of Lauren Alfred and Doris Ruth (Peterson) Lundblad.
Bachelor of Science, Pacific Lutheran University, 1961. Doctor of Philosophy, University Washington, 1965.
Research associate, U. Washington, Seattle, 1965-1966; research associate, Rockefeller U., New York City, 1966-1968; assistant professor, U. North Carolina, Chapel Hill, 1968-1971; associate professor, U. North Carolina, Chapel Hill, 1971-1977; professor pathology and biochemistry, U. North Carolina, Chapel Hill, 1977-1991; Adjunct Professor, since 1991; director science technical development, Baxter-Hyland/Immuno, Duarte, California, since 1991. Visiting scientist Hyland division Baxter Healthcare, Glendale, California, 1988-1989.
( Reflecting the versatility of the author’s science and ...)
( The activity of many biopharmaceutical polymers is depe...)
(Largely driven by major improvements in the analytical ca...)
(Chemical Reagents for Protein Modification, 2nd Edition p...)
(Chemical Reagents for Protein Modification, 2nd Edition p...)
(Chemical Reagents for Protein Modification, 2nd Edition p...)
(Revised and updated, Chemical Reagents for Protein Modifi...)
(While biomedical investigation has greatly advanced, inve...)
(This exciting laboratory support book encompasses the enc...)
( The use of the chemical modification of proteins has ev...)
Member American Society Bio-chemical Molecular Biology, American Society Microbiology, American Heart Association, Sigma Xi.
Married Susan Hawly Taylor, October 15, 1966 (divorced 1985). Children: Christina Susan, Cynthia Karin.