In 1971, she made her debut as actress with the film Sacco e Vanzetti. Foreign her performance she was awarded with a Nastro d"Argento as best new actress. Her other roles were in the crime films The Black Hand (1973) and Cross Shot (1976).
In 1972, she topped the Hit Parade with her major success, the song "Sono una donna, non sono una santa".
In the following years she experimented with various genres such as disco music, folk music and Italo disco and competed in a number of Sanremo Festivals, but failed to repeat that success. In 1985, Fratello took part to the musical project Ro.Bo.T. together with Bobby Solo and Little Tony.