She was a native of Ottawa, Ontario. She is best known for portraying Mary Roberts in Laurel and Hardy"s 1937 film Way Out West. She is also recognizable as Mission Lawrence, the schoolteacher in the Our Gang comedies from 1936 to 1937 and as Alice Lowell in Charlie Chan"s Secret in 1936.
In 1937 she played a starring role as Cecilia Moore in Pick A Star.
Her final performance was in the 1939 Italian comedy film In the Country Fell a Star in which she plays an American film star who causes great excitement when she appears in a small Italian town. Lawrence and Juvenal P. Marchisio married in 1939, and she left acting to become a housewife.
Marchisio died in 1973, and in 1987, Lawrence married John McCabe, biographer of her onetime co-stars Laurel and Hardy. Rosina Lawrence died of cancer on June 23, 1997 at the age of 84.