Born Ruby Burkhardt, she began her stage career with the Midnight Frolic, a Florenz Ziegfeld show, in New York City. Her first film role came in 1917 in Enlighten Thy Daughter, a picture directed by Ivan Abramson. The Fox Film comedy, The Evil Eye (1920), starred De Remer, Catherine Calvert and Eugene O"Brien.
As Christine, in Pilgrims of the Night (1921), she played a hand organ while a monkey on a leash accompanied her through the streets of New York City.
She worked for Associated Producers, acting opposite Lewis Stone in a number of films. One of these was Passersby, a Frothingham production, adapted from the East. Phillips Oppenheim novel.
Among her final starring films were three features directed by Marcel Perez: The Way Women Love (1920), Luxury (1921), and Unconquered Woman (1922). French artist Paul Helleu chose De Remer as his ideal of American beauty in 1920.
Florenz Ziegfeld called De Remer the most beautiful blonde since Venus.