She accompanied him on the first Migration to Abyssinia, where she suffered a miscarriage. They returned to Abyssinia in 616, and there Ruqayyah gave birth to a son, Abdullah, in 619. Abdullah died when he was six years old in Medina.
She had no further children.
Uthman and Ruqayyah were among those who returned to Mecca in 619. Uthman emigrated to Medina in 622, and Ruqayyah followed him later.
Ruqayyah was said to be extremely beautiful. When Usama ibn Zayd was sent on an errand to their house, he found himself staring at her and at Uthman in turns.
Muhammad asked Usama, "Have you ever seen a more handsome couple than those two?" and he agreed that he had not.
Ruqayyah fell ill in March 624. Uthman was excused from his military duties in order to nurse her. She died later in the month, on the day when Zayd ibn Harithah returned to Medina with news of their victory at the Battle of Badr.
When Muhammad returned to Medina after the battle, the family went to grieve at her grave.
The women wept noisily, and Umar hit them with his whip. But Muhammad said: "Let them weep, Umar.
But beware of the braying of Satan.".