She is known for her role in the 1997 comedy film Home Alone 3, and for recurring roles in television series Dexter and Nashville. She is of Swedish descent. In 1994, Kihlstedt married actor Gil Bellows They have two children, Ava Emanuelle (born 1999), and Giovanni (born 2001).
She is the sister of Oakland-based violinist, Carla Kihlstedt.
In 1995, Kihlstedt portrayed Lizzie Elmsworth in the British Broadcasting Corporation adaptation of Edith Wharton"s last novel, The Buccaneers. However, she is best known for portraying Alice, one of the criminals in the comedy Home Alone 3 (1997).
In 1998, She starred with Peter Gallagher in the film Brave New World. She appeared in recurring roles on Showtime drama series Dexter as Doctor Michelle Ross, and on American Broadcasting Company drama series Nashville as powerful record producer Marilyn Rhodes.
As of 2015, she is starring as Erica Kravid on the National Broadcasting Company series Heroes Reborn.
Others notable television credits include Early Edition, Criminal Minds and NCIS, and supporting roles in the films Arctic Blue, Deep Impact, Jaded and Women in Trouble.