She graduated from Northwestern University.
Most notably, she was the co-host of seasons two through nine of Dancing with the Stars with Tom Bergeron. From 2010-2012, she was a correspondent at Entertainment Tonight. In September 2015, she returned to the program as a co-anchor for the weekend edition
She had a Jewish upbringing.
On December 16, 2008, Harris joined The Insider as a substitute host and correspondent. She had previously been a correspondent with East! Entertainment Television"s East! News, and host of THS Investigates.
She has also appeared as a special correspondent on Good Morning America. Prior to joining East!, Harris served as a weekend co-host for the infotainment show Extra, where she interviewed hundreds of celebrities and served as an anchor for the show"s Las Vegas bureau.
Her best known hosting job was for Dancing with the Stars along with Tom Bergeron.
She took over in 2006 for Lisa Canning. Her other hosting credits include Fox"s The Next Joe Millionaire and Administrative Management College Access (the short-lived spinoff of Access Hollywood produced for Administrative Management College). Additionally, she also served as a guest co-host on The View.
She hosted a week of Who Wants to Be a Millionaire shows on May 11–15, 2009.
Harris announced on January 28, 2010 that she would leave Dancing with the Stars to focus on other projects like her correspondent duties at The Insider and Entertainment Tonight. Burke was later replaced in 2014 by Erin Andrews.
Her film and television credits include D3: The Mighty Ducks, Surviving Gilligan"s Island (in which she portrayed the actress Dawn Wells), Reefer Madness, Beautiful, Computer Society of India: Crime Scene Investigation, among others She made her Broadway debut in 2009 as Roxie Hart in Chicago.
She performed a six-week engagement in the long-running musical from July 7 through August 16 at the Ambassador Theatre.
After her Broadway run, Harris played Roxie in the Greenville, South Carolina, engagement of the national tour, August 18–23, at the Peace Center. Harris has been a three-time cover girl model for Muscle & Fitness: HERS, and for FHM, SELF and Supreme Headquarters Allied Powers in Europe magazines, and in various ads and commercials. She was featured in the December 2006 issue of FHM magazine.
In November 2007, Harris was announced as the spokesperson for Palmer"s Cocoa Butter Formula line, where she was featured in a national print and television campaign.
Harris supports cancer research and volunteers for such charity events as Feeding America and the Revlon Run/Walk and What A Pair.