Nott was born on 11 September 1788 in Franklin, Connecticut. His father Samuel Nott Senior (1754–1852) was the pastor of Congregational Church, Franklin.
And patriarch of the New England clergy.
Nott Junior. was admitted to his father"s church in 1805. Under the guidance of his father, his education commenced in his early childhood.
He graduated at Union College in July 1808, and at Andover Theological Seminary in 1808.
He was one of the first five foreign missionaries under American Board of Commissioners for Foreign Missions to India, and established Bombay Mission station, the first Americans overseas mission station at Bombay, then-headquarters of Bombay Presidency. He published several sermons and books, notably, Sixteen Years" Preaching and Procedure at Wareham, Slavery and the Remedy, and many more. However, Mills stayed back in United States to oversee their cause.
Judsons, later made their way to Serampore to work with the Baptist mission operating there - Luther Rice reverted to United States to solicit funds for establishment and maintenance of Baptist Mission in India.
Unlike their fellow-missionaries, Samuel Nott and Gordon Hall escaped Calcutta and found refuge in Bombay, where they started a covert mission work. The mission station was later to be called as Bombay Mission, the first mission station by Americans overseas.
Over the period, Hall and Nott established their mission stations at Thane and Mahim. Their missionary activities included preaching the gospel, translating the scriptures into local languages, publishing evangelical Christian literature, and operating schools.
One school operated by them instructed Jewish children in Hebrew and Marathi language.
With broken health, he returned to the United States in 1816, and joined as a school-teacher in New York City till 1823. Between 1823 and 1829, he served as a pastor at Galway, New York, and at Wareham from 1829 to 1849. Later, he founded a private Academy at Wareham, where he served between 1849 and 1866.
After he retired from active labours, he resided at Wareham and Hartford, and died in Hartford on 1 June 1869.
