He was an apprentice in the workshop of Adam van Noort, who also trained many illustrious painters such as Peter Paul Rubens, Jacob Jordaens and Hendrik van Balen. He also visited the workshop of the Antwerp painter Paul Bril in Rome around 1600. He was esteemed as one of the main painters of battle scenes, and works by Vranckx were in the collection of Peter Paul Rubens.
As a collaborator he worked at times with January Brueghel the Elder. and together with Rubens, Frans Francken the Younger, van Balen, Frans Snyders and Joos de Momper the Younger on the Allegory of the Senses, two works commissioned on the occasion of the archduke Albert of Austria"s visit to Antwerp.
His best-known student is Pieter Snayers. Most of his pictures represent biblical scenes or scenes of war, such as the sack of towns, cavalry combats, genre paintings and allegorical subjects.
He was at the same time a writer of poetry, comedies and tragicomedies for the chamber of rhetoric De Violieren. He was served as dean of the Antwerp painters" Guild of Saint Luke, and was a district head and captain of the militia.
He is also represented with several drawings or paintings at the Hermitage in Saint St. Petersburg, the Harvard University Art Museums, the Louvre, Paris, the Museum of Fine Arts of Seville and several other museums.
Although he was primarily a painter of landscapes and small battle scenes, Vranckx also painted architectural interiors in the manner of Pieter Neeffs I.