Background
Hakomori, Sen-Itiroh was born on February 13, 1929 in Sendai, Japan. Arrived in the United States, 1963, naturalized, 1978. Son of Shinichiro and Kiku (Amae) Hakomori.
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book
Sphingolipid Biochemistry (Handbook of Lipid Research)
(Interest in and emphasis upon different aspects of the sp...)
Interest in and emphasis upon different aspects of the sphingolipids have, in general, followed the biochemical developments of the day. The early inves- tigators were preoccupied principally with the isolation of "pure" compounds and structural elucidation. This historical perspective is found in the discus- sion presented in Chapter 1 (Section 1. 1. 2 and Table III). Still, the isolation and structural characterization of glycolipids are the basic foundation of all our knowledge of enzymology, immunology, and cell biology. Recent infor- mation obtained on structure has greatly affected the interpretation of various phenomena related to glycolipids. New structures suggest a new role of gly- colipids as antigens and receptors. Ten years ago, only four neutral glycolipids and two gangliosides were known in human erythrocytes. We now know structures of at least twenty additional neutral glycolipids and ten additional gangliosides in human erythrocytes that are known to be important blood group, heterophil, and autoantigens. Erythrocytes are only one example of a cell type whose glycolipid profile has been extensively studied. Our defective knowledge in immunology and cell biology may be due to incomplete un- derstanding of structural chemistry. Modern methodology based on methyla- tion analysis, mass spectrometry, and enzymatic degradation has supple- mented classical analysis based on clorimetry. Nuclear magnetic resonance spectroscopy is still in the development stage, but will eventually replace var- ious chemical analyses. However, important future studies should be directed toward elucidating the organizational structure of glycolipids in membranes.
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Senator-itiroh Hakomori
Edit Profilebiochemist educator immunochemist researcher
Education
Doctor of Medicine, Tohoku University, Sendai, 1952. Doctor in Medical Science, Institute Biochemistry, 1957.
Career
Intern, Sendai City Hospital, Japan, 1952-1953, assistant professor Tohoku University, 1957-1959, professor College Pharmacy, 1959-1963. Research associate.Med. School, Harvard University, Boston, 1963-1966. Visiting professor Brandeis University, Waltham, Massachusetts, 1966-1968.
Associate professor, then professor of University Washington, Seattle, 1968.
Program head, professor pathobiology and microbiology F. Hutchinson Cancer Center and University Washington, Seattle, 1975-1986. Scientific director The Biomembrane Institute, Seattle, 1986.
Member study section National Institutes of Health, Bethesda, Maryland., 1975-1978, member of advisory committee, Cancer Research Institute, 1987.
Achievements
Works
book
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Sphingolipid Biochemistry (Handbook of Lipid Research)
(Interest in and emphasis upon different aspects of the sp...)
- HANDBOOK OF LIPID RESEARCH 3 SPHINGOLIPID BIOCHEMISTRY
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Sphingolipid Biochemistry (Handbook of Lipid Research)
Membership
Member of Complex Carbohydrate Society, British Biochemical Society, American Society Immunologists, American Association Cancer Research, American Society Biological Chemists, Japanese Cancer Society (honorary), Finnish Science Society (honorary).
Connections
Married Mitsuko Ito, June 16, 1956. Children: Yoichiro, Kenjiro, Naoko.
Education
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1952
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1957
Career
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1952 - 1953
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1957 - 1959
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1959 - 1963
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1963 - 1966
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1966 - 1968
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1968
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1975 - 1986
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1975 - 1986
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1986
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Awards
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Named Outstanding Investigator, National Cancer Institute, 1986, 1993. Recipient Philip Levine award, American Society Clinical Pathology, 1984, Cancer Research Institute, since 1987, Morton lecturer award, 1992.Named Outstanding Investigator, National Cancer Institute, 1986, 1993. Recipient Philip Levine award, American Society Clinical Pathology, 1984, Cancer Research Institute, since 1987, Morton lecturer award, 1992.