In 1944 and Doctor of Philosophy in 1954 from the University of Tokyo. He was Guest Investigator of the Rockefeller Institute in New York from January to December 1959, where he studied with Fritz Lipmann.
He is famous for discovering the protein troponin in 1965, which is integral to muscle contraction. He was Professor and Chair of Pharmacology at the Faculty of Medicine, University of Tokyo, from May 1959 until March 1983. He was also Professor and Chair of Biophysics at the School of Science, University of Tokyo from May 1971 to March 1983.
After retiring from the University of Tokyo and becoming Professor Emeritus, he was offered a professorship in the National Institute for Physiological Sciences in Okazaki.
He became Director-General of National Institute for Physiological Sciences in April 1985, and President of Okazaki National Institutes including National Institute for Physiological Sciences in March 1991. After retiring from this position, he became Professor Emeritus of the National Institute for Physiological Sciences in March 1993.
Member of Japan Academy (Secretary-General 2000), Academy Europaea, Academy National dei Lincei, Academy Royal Medicine de Belgique, German Academy Leopoldina, Royal Society (London), American Academy Arts and Sciences, American Society Biochemistry and Molecular Biology, National Academy of Sciences, American Physiological Society (honorary).
Married Fumiko Takeda, May 20, 1956.