Background
Inoué, Shinya was born on January 5, 1921 in London, England. Son of Kojiro and Hideko (Yano) Inoué. came to United States, 1948, naturalized, 1989.
井上 信也
educator Microscopy and cell biology scientist
Inoué, Shinya was born on January 5, 1921 in London, England. Son of Kojiro and Hideko (Yano) Inoué. came to United States, 1948, naturalized, 1989.
Rigakushi, Tokyo University, 1944. Master of Arts, Princeton University, 1950. Doctor of Philosophy, Princeton University, 1951.
Master of Arts (honorary), Dartmouth College, 1959. Master of Arts (honorary), University Pennsylvania, 1966.
His research field is the visualization of dynamic processes within living cells using light microscopy. Currently he is a researcher at the Marine Biological Laboratory. Inoue can be considered the father of the field of cytoskeleton dynamics.
In the 1940s and 50s he built the first microscope capable of imaging dynamic processes in live cells, using polarized light, and proved for the first time that the mitotic spindle is composed of aligned protein fibers.
We now know these fibers are microtubules. By perturbing cells with agents that cause microtubules to depolymerize (eg colchicine or high pressure) or polymerize excessively (eg D2O), Inoue demonstrated that spindle fibers are in a state of rapid dynamic equilibrium with a pool of soluble subunits in the cytoplasm.
He went on to show that artificial polymerization and depolymerization of spindle fibers can generate forces within the cell, and proposed that chromosomes are normally moved by such forces during mitosis. These ideas were summarized in a seminal review in 1967.
He also was the first to develop video microscopy, and wrote a major textbook on the subject.
Consistent with Inoue"s pioneering ideas, it is now widely believed that chromosome movement during mitosis is powered by microtubule depolymerization. We also know that force generation by polymerization and depolymerization of cytoskeletal protein fibers is perhaps the most ancient of motile mechanisms within cells, whose use extends back to bacteria. 1951 Doctor of Philosophy
(The current edition of Video Microscopy has been totally ...)
(The current edition of Video Microscopy has been totally ...)
(Ever since television became practical in the early 1950s...)
(Society of General Physiologists Series, volume 30)
Trustee Marine Biological Laboratory, 1970-1977, 81-85, 92-96, member science council, 1993-1998. Fellow American Academy Arts and Sciences, Royal Microscopial Society (honorary). Member National Academy of Sciences, Biophysics Society (council 1968-1971), Society General Physiologists (council, president 1962-1965, 69-70), American Society Cell Biology (council 1970-1973, E.B. Wilson award 1992), Optical Society of America, Microscopy Society of America (Distinguished Scientist award 1995), New York Microscopical Society (Ernst Abbe award 1997), Japan Society Promotion of Science (International Prize Biology, 2003).
Married Sylvia McCandless, July 18, 1952. Children: Heather C., Jonathan H., Christopher W., Stephen K., Theodore D.