Career
Reggina
A native of Reggio Calabria, he made his Serie A debut with the local team Reggina on 24 April 2005 against Brescia Calcio. He also spent the 2008-2009 season on loan at Treviso, and returned to Reggina to help his hometown club in their 2009-2010 Serie B campaign. In January 2011 he left for Cagliari in a temporary deal for €1 million.
Sassuolo
On 4 January 2012, Missiroli moved to Serie B side United States. Sassuolo Calcio for €3.5 million.
Before leaving Reggina, Missiroli was one of the team topscorer of 2011-2012 season as a playmaker. Missiroli was the captain of the team such as the game against Sassuolo.
On 11 January 2016 he signed a new 4½ year contract with Sassuolo.
