In 1998, Song made her film debut playing dual roles as an art gallery employee and a soldier"s ex-girlfriend in Lee Jeong-hyang"s critically acclaimed romantic comedy Art Museum by the Zoo, opposite Ahn Sung-ki. This was followed by the gangster comedy My Boss, My Hero (2001). Though Song is more active in television, notable in her filmography are two arthouse films by auteur Hong Sang-soo.
Foreign Woman on the Beach (2006), she and her co-stars agreed to appear in the film even without reading Hong"s script.
While in The Day He Arrives (2011), Song played a film studies professor who frequents a bar in Bukchon. Back on the small screen, her popularity rose when she played a young housewife in Precious Family (2004), written by Kim Soo-hyun.
Leading roles followed in The Secret Lovers (2005), One Day Suddenly (2006), Green Coach (2009), Mistress Town (2009), and Dandelion Family (2010), as well as a supporting role in the well-received medical drama Behind the White Tower (2007).
In 2012, Song was cast as a capable trauma nurse in Golden Time.
She later reunited with its director Kwon Seok-jang in Mission of Korea (2013), set in 1997 during the International Monetary Fund crisis. Song starred in her first ever period drama in 2013"s Cruel Palace - War of Flowers. She drew praise for her portrayal of the Crown Princess Lady Kang, Crown Prince Sohyeon"s wife, despite controversy involving a breastfeeding scene.