He graduated from Bologna"s Theatrical School in 1993, and acted in the theatre for several years before moving to cinema.
In 1995 he played the lead in Jack Frusciante è uscito dal gruppo, one of his best known films. He was the lead in the successful film L"ultimo bacio (The Last Kiss). In 2001, Accorsi also had the leading role in Ferzan Özpetek"s Le fate ignoranti (His Secret Life – Festival Title/The Ignorant Fairies – International Title), which was in competition at the 2001 Berlin International Film Festival.
He also starred in David Blair"s Tabloid television (United Kingdom) and in Marco Ponti"s Santa Maradona.
Then Accorsi acted in the television film Il giovane Casanova by Giacomo Battiato. He didn"t make any more films for about a year, during which time he went to France.
In 2004 he shot two movies: Ovunque science, directed by Michele Placido, where he plays the role of an emergency care doctor. And L"amore ritrovato, directed by Carlo Mazzacurati.
Accorsi works with Diane Kruger in and with Julie Depardieu in Louisiana Faute à Fidel.
He then acts in Un baiser s"il vous plaît in 2007 and its sequel Baciami ancora in 2010.
He went to the Venice International Film Festival 2003 as a member of the jury.