Education
In 1967, he received his Doctor of Philosophy in biophysics from Harvard, was a research fellow there as well as a junior fellow in the Society of Fellows, and joined the Harvard faculty in 1971.
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Stephen Harrison
Edit Profilebiochemist university professor
Stephen C. Harrison is professor of biological chemistry and molecular pharmacology, professor of pediatrics, and director of the Center for Molecular and Cellular Dynamics of Harvard Medical School, head of the Laboratory of Molecular Medicine at Boston Children"s Hospital, and investigator of the Howard Hughes Medical Institute.
Career
He received his Bachelor of Arts in chemistry and physics from Harvard in 1963, and was then a Henry fellow at the Medical Research Council Laboratory of Molecular Biology at Cambridge. His wide-ranging studies of protein structure have contributed insights to viral architecture, deoxyribonucleic acid–protein recognition, and cellular signaling. Harrison has made important contributions to structural biology, most notably by determining and analyzing the structures of viruses and viral proteins, by crystallographic analysis of protein–deoxyribonucleic acid complexes, and by structural studies of protein-kinase switching mechanisms.
The initiator of high-resolution virus crystallography, he has moved from his early work on tomato bushy stunt virus (1978) to the study of more complex human pathogens, including the capsid of human papillomavirus, the envelope of dengue virus, and several components of Human Immunodeficiency Virus. He has also turned some of his research attention to even more complex assemblies, such as clathrin-coated vesicles.
He led the Structural Biology team at the Center for Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome Vaccine Immunology (CHAVI) when it received National Institute of Allergy and Infectious Diseases (National Institute for Allergy and Infectious Diseases) funding of around $300 million to address key immunological roadblocks to Human Immunodeficiency Virus vaccine development and to design, develop and test novel Human Immunodeficiency Virus vaccine candidates.
Achievements
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1988 Wallace P. Rowe Award, National Institute of Allergy and Infectious Diseases 1990 Louisa Gross Horwitz Prize (with Don Wiley and Michael Rossmann), Columbia University 1995 George Ledlie Prize, Harvard University 1997 ICN International Prize in Virology 2001 Paul Ehrlich and Ludwig Darmstaedter Prize (with Michael Rossmann) 2005 Bristol-Myers Squibb Freedom to Discover Award for Distinguished Achievement in Infectious Diseases 2006 Gregori Aminoff Prize in Crystallography 2014 Elected as a Foreign Member of the Royal Society of London.
Membership
Royal Society; National Academy of Sciences]
He is a member of American Academy of Arts and Sciences, National Academy of Sciences, American Philosophical Society, European Molecular Biology Organization, American Crystallographic Association and American Association for the Advancement of Science.
Education
Awards
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Louisa Gross Horwitz Prize; Paul Ehrlich and Ludwig Darmstaedter Prize; Arts and Sciences; Gregori Aminoff Prize 1988 Wallace P. Rowe Award, National Institute of Allergy and Infectious Diseases 1990 Louisa Gross Horwitz Prize (with Don Wiley and Michael Rossmann), Columbia University 1995 George Ledlie Prize, Harvard University 1997 ICN International Prize in Virology 2001 Paul Ehrlich and Ludwig Darmstaedter Prize (with Michael Rossmann) 2005 Bristol-Myers Squibb Freedom to Discover Award for Distinguished Achievement in Infectious Diseases 2006 Gregori Aminoff Prize in Crystallography 2014 Elected as a Foreign Member of the Royal Society of London. The Louisa Gross Horwitz Prize for Biology or Biochemistry is an annual prize awarded by Columbia University to a researcher or group of researchers who have made an outstanding contribution in basic research in the fields of biology or biochemistry.; The Paul Ehrlich and Ludwig Darmstaedter Prize is given every year since 1952 for investigations in medicine.; The Gregori Aminoff Prize is an international prize awarded since 1979 by the Royal Swedish Academy of Sciences in the field of crystallography, rewardingLouisa Gross Horwitz Prize; Paul Ehrlich and Ludwig Darmstaedter Prize; Arts and Sciences; Gregori Aminoff Prize 1988 Wallace P. Rowe Award, National Institute of Allergy and Infectious Diseases 1990 Louisa Gross Horwitz Prize (with Don Wiley and Michael Rossmann), Columbia University 1995 George Ledlie Prize, Harvard University 1997 ICN International Prize in Virology 2001 Paul Ehrlich and Ludwig Darmstaedter Prize (with Michael Rossmann) 2005 Bristol-Myers Squibb Freedom to Discover Award for Distinguished Achievement in Infectious Diseases 2006 Gregori Aminoff Prize in Crystallography 2014 Elected as a Foreign Member of the Royal Society of London. The Louisa Gross Horwitz Prize for Biology or Biochemistry is an annual prize awarded by Columbia University to a researcher or group of researchers who have made an outstanding contribution in basic research in the fields of biology or biochemistry.; The Paul Ehrlich and Ludwig Darmstaedter Prize is given every year since 1952 for investigations in medicine.; The Gregori Aminoff Prize is an international prize awarded since 1979 by the Royal Swedish Academy of Sciences in the field of crystallography, rewarding