Aged 18, Meis decided that she wanted to be a model and was cast for various shoots by casting agencies. After becoming interested in television, she gained popularity through assignments at FoxKids and music station TMF. She hosts several events at TMF, such as presenting the annual TMF-awards, and conducting interviews with international artists such as Britney Spears and Kylie Minogue. In addition, she features in video clips and the Dutch television-series Costa.
She also introduced the Pure by Sylvie jewellery line to the Dutch market.
After being elected the Netherlands" Sexiest Female in 2003, she started a relationship with then-AFC Ajax football player Rafael van der Vaart. Due in part to the fame from their individual careers, they soon became the Netherlands" most famous "football couple".
Since 2008, she has been a judge on Das Supertalent, the German version of Simon Cowell"s Got Talent series. She is currently taking part in the third season of the German equivalent of Strictly Come Dancing, called Let"s Dance.
On 17 April 2010, Meis replaced the usual Deutschland sucht den Superstar judge Nina Eichinger for the final of the 7th season, after the latter was stuck in Los Angeles following flight restrictions as a result of the 2010 eruptions of Eyjafjallajökull.
In March 2011 Meis was going to host the show Let"s Dance together with Daniel Hartwich. Following in the footsteps of famous entertainers such as Johannes Heesters and Rudi Carell, Meis is one of the most successful Dutch personalities active in Germany.