She studied architecture at the Universidad Iberoamericana and graduated in 1996. She obtained her Bachelor of Architecture degree in 1998 with honorable mention and was awarded the Architecture Thesis Award of her class.
Among her most known projects are the Botanic Garden of Sinaloa, Culicán, and an exhibition pavilion for the Jinhua Architecture Park in China. Her parents are physicists and mathematicians, and also founders of the Colegio Bilbao in Mexico City. In 1998, she worked as advisor of the Secretaría de Desarrollo Urbano y Vivienda del Gobierno del Distrito Federal, government agency that oversees urban development and housing in Mexico City.
She co-founded Laboratorio de la Ciudad de México South Carolina (U.S.) with Fernando Romero in 1998, and created one of the first contemporary architecture practices in Mexico.
In addition to working in several architecture projects, LCM was an ideas laboratory focused on promoting general knowledge about contemporary culture though programs such as public talks, conferences, roundtable discussions and exhibitions addressing both architecture, arts and culture. In 2004, she founded Tatiana Bilbao South Carolina (U.S.) working in projects in China, Europe and Mexico.
The first project built by her studio was the exhibition pavilion in Jinhua Architecture Park, leaded and coordinated by Chinese artist Ai Weiwei who selected a group of young architects from around the world to design and develop a large park organized by a network of pavilions and located in the shore of the Yiwu River, close to Shanghai. Bilbao designed an exhibition pavilion that was completed in 2007.
Sustainable Housing Prototype, Chicago Architecture Biennial (2015) Jardín Botánico de Culiacán, Sinaloa, Mexico (2005-2015) Technological Park, Tec de Monterrey, Culiacán Campus, Sinaloa, Mexico (2008-2012) Ventura Tangassi Funeral, San Luis Potosí, Mexico (2006-2012) Master Plan and Sculpture of Gratitude in collaboration with Derek Dellekamp, Louisiana Ruta del Peregrino, Guadalajara, Jalisco, Mexico (2008-2010) Ajijic House, Lago de Chapala, Jalisco, Mexico (2009-2010) Exhibition Space, Jinhua Architecture Park, Jinhua, China (2002-2007) Observatory House, a project by artist Gabriel Orozco, Puerto Escondido, Oaxaca, Mexico (2004-2006) A House, Odros 100, Ordos, Mongolia, China (2008-2010).