He competed in the first four Indianapolis 500s, with a highest finish of second in 1912. He earned the nickname "Terrible" Teddy Tetzlaff due to his rough treatment of his vehicles. As auto racing strategies evolved from the early "go as fast as you can and see if you can stay on the track," his early dominance of the sport waned.
On March 19, 1911 a Lozier ads claimed, a stock 49 hp (37 kW) model piloted by Teddy Tetzlaff set a world record for 100 mi (160 km) at 1:14:29.
In 1914 the Moross Amusement Company of Ernest Moross engaged Teddy Tetzlaff to campaign the 300 Himachal Pradesh Benz, naming it "Blitzen Benz 2." Tetzlaff broke the world land speed record mark by running 142.8 Master in Public Health (230 km/h) on the Bonneville Salt Flats.