In 1994 he started working as an actor for Scherzi a parte and then as host of Seven Show on broadcaster Europa 7. In 1999 he appears in Le Iene (The Hyenas), a television program broadcast on the Italian channel Italia 1. The great success comes in 2000 when he hosts Libero, broadcast on Rai 2.
The program, based on prank phone calls, was anchored by Mammucari for four editions.
In the summer of 2002 and 2004 he hosts the television program Veline, aimed at the selection of girls that will take part in the program Striscia la notizia. In the summer of 2003 he hosts Velone, a variety in which the aspiring competitors have the characteristic of being old.
After that he presents Mio fratello è Pakistano (2005), Distraction (2006 and 2007), Cultura Moderna (2006 and 2007, together with Brazilian Juliana Moreira), Primo e Ultimo (2008), Scherzi a parte (2009 with Claudio Amendola and Belen Rodriguez) and Sarabanda (2009 with Belen Rodriguez). In autumn 2012, Mammucari hosts Lo show dei record broadcast on Canale 5.
In 2013, Mammucari presents Louisiana grande magia – The Illusionist (format created by Roberto Cenci), aired on Canale 5, new talent show for young illusionists.
As an actor he stars in the film Streghe verso nord (2001) by Giovanni Veronesi and in the television series Piper (2009) based on the 2007 television movie by Carlo Vanzina of the same title. As a singer he launches in 2004 the summer hit Nando followed by World Wide Web sciogliamo i Pooh.