Ramsaye started his professional career as an engineer but switched to journalism when he joined the staff of the Kansas City Star and Times in 1905. In the following decade, he worked on newspapers in Leavenworth, Kansas, and in Omaha, Saint Paul, Minnesota, and Chicago. The motion picture industry was in its infancy when he joined Mutual Film Corporation in 1915.
Subsequently he was associated with Samuel Roxy Rothafel in the management of Broadway"s Rialto and Rivoli theaters.
He also launched and edited the newsreel Kinograms. After producing and editing numerous adventure films including Grass (1925) and Simba: King of the Beasts (1928) with explorers Martin and Osa Johnson, he became editor-in-chief of Pathé News and Audio Review.
In 1931, Ramsaye joined the Quigley Publishing Company as editor of the Motion Picture Herald, a post he held until 1941. Subsequently, he lectured on motion pictures and contributed articles to various encyclopedias and year books
He continued his association with Quigley as consulting editor and author of a weekly column for the Herald until his death in 1954.
Thomas Edison"s endorsement is included in the book H. L. Mencken spoke highly of lieutenant