Education
Kelly earned a Doctor of Philosophy in biophysics in 1968 and an Doctor of Medicine
biologist geneticist university professor
Kelly earned a Doctor of Philosophy in biophysics in 1968 and an Doctor of Medicine
Kelly is director of the Sloan-Kettering Institute, the basic research arm of the Memorial Sloan-Kettering Cancer Center. He holds the Center"s Benno C. Schmidt Chair of Cancer Research. Before joining Sloan-Kettering in 2002, Kelly was professor and director of the Department of Molecular Biology and Genetics at the Johns Hopkins University School of Medicine and was the founding director of the Johns Hopkins Institute for Basic Biomedical Sciences.
Kelly pioneered the study of deoxyribonucleic acid replication in eukaryotic cells by using deoxyribonucleic acid viruses as model systems
His laboratory developed the first cell-free systems for studying the biochemistry of deoxyribonucleic acid replication in human cells, enabling the identification and functional characterization of components of the human replication machinery. in 1969. While a postdoctoral fellow with Hamilton O. Smith at the Johns Hopkins University School of Medicine during 1969-1970, Kelly determined the deoxyribonucleic acid sequences recognized by restriction enzymes, which are major tools in recombinant deoxyribonucleic acid research.
He joined the faculty in the Department of Microbiology at the Johns Hopkins University School of Medicine in 1972, where he began to exploit viruses as potentially powerful model systems for exploring the mechanisms of deoxyribonucleic acid replication in human cells. Using proteins derived from human cells, he and his colleagues developed the first cell-free deoxyribonucleic acid replication systems capable of duplicating the complete genomes of adenovirus and SV40.
The SV40 system proved to be a particularly useful system because SV40 relies largely on the cellular replication machinery for the duplication of its genome.
Thus, biochemical analysis of the SV40 system made it possible to identify and functionally characterize proteins and enzymes that carry out the duplication of the chromosomal deoxyribonucleic acid in human cells. In subsequent work Kelly and colleagues have shifted their focus from studying the machinery of deoxyribonucleic acid replication to the mechanism that controls lieutenant Studying these mechanisms are essential for ensuring the accuracy of deoxyribonucleic acid replication during the cell cycle in human cells and in fission yeast (Schizosaccharomyces pombe), which is highly significant in understanding cancer.
Since 2002, Kelly has been the director of the Sloan-Kettering Institute, where he has expanded or re-invigorated some of its laboratory research programs.
Kelly also led the establishment of the Gerstner Sloan-Kettering Graduate School of Biomedical Sciences, which provides a novel curriculum in basic and translational cancer biology leading to the Doctor of Philosophy degree. Member, Institute of Medicine.
National Academy of Sciences. American Academy of Arts and Sciences]
In 1970 he moved to the National Institutes of Health as a member of the United States Public Health Service and conducted research on the deoxyribonucleic acid viruses, adenovirus and SV40, which cause tumors in animals.