Thomas Peter Maniatis

Background

Maniatis, Thomas Peter was born on May 8, 1943 in Denver, Colorado, United States. Son of Peter T. and Jane V. (Swearingen) Maniatis.

Education

He received a Doctor of Philosophy in Molecular Biology from Vanderbilt University, and has received Honorary Doctors of Philosophy from the University of Athens and the Watson School of Cold Spring Harbor Laboratory. As a postdoctoral fellow with Mark Ptashne at Harvard University, Maniatis studied the molecular mechanisms of gene regulation in bacteriophage lambda.

Career

Maniatis is a graduate of the University of Colorado and one of the founders of modern molecular cloning. Maniatis carried out postdoctoral studies with Professor Mark Ptashne at Harvard University and with Doctor Fred Sanger at the Medical Research Council Laboratory of Molecular Biology in Cambridge, England. Maniatis has held faculty positions at Harvard University, The Cold Spring Harbor Laboratory, the California Institute of Technology, and Columbia University.

As a graduate student at Vanderbilt University with Doctor Leonard Lerman, Maniatis determined the structure of highly compact deoxyribonucleic acid using wide-angle x-ray scattering methods.

He determined the deoxyribonucleic acid sequence of the lambda operators while working in Fred Sanger"s lab at the Medical Research Council in Cambridge, England. Maniatis was appointed to the position of assistant professor in the Department of Biochemistry and Molecular Biology in 1975, but carried out his research at Cold Spring Harbor Laboratory because the moratorium on recombinant deoxyribonucleic acid research in Cambridge, Master of Arts prevented his work on cDNA cloning at Harvard.

While the moratorium continued Maniatis moved his laboratory to the California Institute of Technology, where he pioneered the development of gene isolation methods. In 1981 Maniatis returned to Harvard where he applied molecular cloning methods to the study of the mechanisms of transcription and Ribonucleic acid splicing in eukaryotes.

Maniatis retired from Harvard in 2009, becoming the Jeremy Knowles Emeritus Professor of Molecular and Cellular Biology.

Maniatis is currently serving as the Isidore Edelman Professor of Biochemistry and Molecular Biophysics at the Columbia University College of Physicians and Surgeons in New New York His laboratory studies innate immunity, mechanisms of gene regulation in the brain, and the causes of the fatal neurodegenerative disease Amyotrophic Lateral Sclerosis (Amyotrophic Lateral Sclerosis or Lou Gehrig"s disease). In 1982 Maniatis along with Joe Sambrook and Edward Fritsch wrote Molecular Cloning: A Laboratory Manual, which has had an enormous impact on life sciences.

This laboratory manual made the newly emerging gene cloning technology accessible to a wide range of disciplines in the life sciences.

Maniatis is also a pioneer in the biotechnology industry, having cofounded Genetics Institute, Incorporated. in 1980, ProScript Pharma in 1994, and Acceleron Pharma in 2004.

Achievements

• Thomas Peter Maniatis has been listed as a noteworthy Molecular biology educator by Marquis Who's Who.

Works

More photos

• book

  • Molecular Cloning: A Laboratory Manual (3 Volume Set)

    (...revised & expanded to include new chapters on oligonuc...)

  • Molecular Cloning: A Laboratory Manual (3 Volume Set) by J. Sambrook (1989-12-03)

Membership

Fellow American Academy of Sciences. Member National Academy of Sciences (Richard Lounsbery award for biology and medicine United States and French National Academy of Sciences, 1985)., American Association for the Advancement of Science, American Academy Microbiology.

Connections

Married Jessie Marion Klyce, August 27, 1968. Children: Ethan David, Silas Dana.

Father:

Peter T. Maniatis

Mother:

Jane V. (Swearingen) Maniatis

Spouse:

Jessie Marion Klyce

child:

Ethan David Maniatis

child:

Silas Dana Maniatis