She was the first ever successful child star of Philippine cinema. In 1938, Sampaguita Pictures spotted the child and cast her in a tear-jerker movie of Inang Mahal aka (Dear Mother). Her second movie in Sampaguita was Ang Magsasampaguita (The Sampaguita Vendor).
Durán made two movies under Licensed Vocational Nursing Pictures and it was Pangarap (Dream) and Sawing Gantimpala (Lost Prize) both in 1940.
After World World War II, she made a comeback in her studio Sampaguita Pictures. She joined in a war film with Carmen Rosales entitled Guerilyera and typecasted in numerous musical films paired by some of the Sampaguita"s finest actor.
After her last movie in Sampaguita Isang Halik Mo Pancho, she made Maria Went to Town under Deegar Cinema Incorporated.