Background
Jackson was born on July 24, 1972, in Monroe, Louisiana, United States; the daughter of Isaiah and Ernestine Jackson.
(To profoundly understand biology and harness its intricac...)
To profoundly understand biology and harness its intricacies for human benefit and the mitigation of human harm requires cross-disciplinary approaches that incorporate sophisticated computational and mathematical modeling techniques. These integrative strategies are essential to achieve rapid and significant progress in issues, in health and disease, which span molecular, cellular and tissue levels. The use of mathematical models to describe various aspects of tumor growth has a very long history, dating back over six decades. Recently, however, experimental and computational advances have improved our in the understanding of how processes act at multiple scales to mediate the development of tumor vasculature and drive the advancement of cancer. This book will showcase the development and utilization of new computational and mathematical approaches to address multiscale challenges associated with tumor vascular development. In Part I: Cell Signaling and Molecular Aspects of Tumor Blood Vessel Formation, it will be come clear that mathematical modeling can help to biochemically and biomechanically phenotype one of the most important cell types involved in cancer progression: vascular endothelial cells. When subverted by the tumor modulated environment, vascular endothelial cells form a new vascular supply capable of nourishing and translocating cancer cells to other tissues. The models in Part I illustrate the importance of quantitative approaches for gaining a deeper understanding of how normal and abnormal aspects of signal integration culminate in the cell proliferation, migration, and survival decisions that result in pathological tumor angiogenesis. The focus of Part II is the angiogenesis cascade and all of its complexities. Successful angiogenesis is mediated by the intricate interplay between biochemical and biomechanical mechanisms, including cell-cell and cell-matrix interactions, cell surface receptor binding, and intracellular signal transduction. A major challenge facing the cancer research community is to integrate known information in a way that improves our understanding of the principal underpinnings driving tumor angiogenesis and that will advance efforts aimed at the development of new therapies for treating cancer. The chapters in Part II will highlight several mathematical and computational approaches for that can potentially address this challenge. While the first two thirds of the book’s chapters demonstrate how important insights can be gained by studying cell signaling and vascular morphology and function, the series of chapters in Part III: Whole Organ Modeling of Tumor Growth and Vasculature, will integrate vasculature development with tumor growth dynamics. These two processes strongly depend on one another in ways that can only be theoretically investigated by biophysical approaches that cut across several levels of biological organization and describe both the tumor and the developing vasculature as they co-evolve. The purpose of this edited volume is not to provide a comprehensive review of all modeling efforts that address tumor vascular modeling; instead, a variety of interesting and innovative mathematical modeling approaches for understanding the development and effects of tumor vasculature are highlighted in order to illustrate some of the emerging trends in the field.Â
http://www.amazon.com/gp/product/1493901338/?tag=2022091-20
2014
Jackson was born on July 24, 1972, in Monroe, Louisiana, United States; the daughter of Isaiah and Ernestine Jackson.
Jackson graduated with an honorary degree of a Bachelor of Science in Mathematics from Arizona State University in 1994. She received a Master of Science degree in Applied Mathematics from University of Washington in 1996 and Doctor of Philosophy degree in Applied Mathematics in 1998. Her thesis was "Mathematical Models in Two-Step Cancer Chemotherapy".
Jackson began her career as a Research Associate and John Hope Franklin Postdoctoral Fellow in the Mathematics at Duke University in 1998. In 2000, she joined the faculty at the University of Michigan as an assistant professor in the mathematics department. Jackson was promoted to associate professor in 2003.
In 2006, Trachette was appointed as the co-principal investigator of the National Science Foundation, funded University of Michigan SUBMERGE (Supplying Undergraduate Biology and Mathematics Education Research Group Experiences) program.
In 2008, Jackson served as senior editor for the academic journal "Cancer Research". The same year she became a full professor on the faculty of the Mathemtics Department at the University of Michigan.
Jackson is the co-founder and co-director of the the Mathematics Biology Research Group.
(To profoundly understand biology and harness its intricac...)
2014Jackson is a member of Association for Women in Mathematics, Society for Industrial and Applied Mathematics, Society for Mathematics Biology.
On August 8, 1998 Trachette Jackson married Patrick Nelson. They have 2 children.