She attended Pickens High School in Jasper, Georgia. In 1987, during her senior year, she left Jasper to take drama classes in Miami, and later attended State University of New York Purchase.
Middendorf is married to Franz Wisner, author of the well-received book Honeymoon with My Brother, and has two children. Middendorf broke into television as Carrie Brady on the daytime soap opera Days of Our Lives in 1992, replacing Christie Clark until her return in 1993. In 2005, she appeared as a worried mother in House and had a major role in El Cortez as Jack"s girlfriend, Theda.
Middendorf just wrapped shooting on the pilot The Last Ship for TNT and wrapped shooting in Brazil for three months on the film The Art of Losing (Flores Raras).
On stage, she was most recently seen at the Shakespeare Theatre Company in Old Times and Yale Repertory Theatre in Battle of Black and Dogs. She recently appeared in the first three seasons of Boardwalk Empire as Babette, the hostess and manager of the Atlantic City restaurant Babette"s Supper Club.
In 2015, Middendorf joined the cast of the Music Television series SCREAM, based on the Wes Craven smash thriller, as Margaret "Maggie" Duval, a woman with a secret past that has caught up to her and her young teenage daughter, putting their lives at risk. Philanthropy
In 2012, Middendorf created Shutter To Think— a project designed to use photography as a way to support programs for girls around the world.
Through the sale of personal photographs taken by well-known actors, writers, directors, and musicians, Shutter to Think is able to help fund programs with globally recognized organizations that are focused on providing opportunities to girls.
Contributors include Steve Buscemi, Meryl Streep and Nicholas Doctorate. Kristof, among others