Moore was drafted by the Washington Nationals in the 16th round of the 2008 Major League Baseball Draft out of the Mississippi State University. Moore was drafted two times previously, both by the Nationals. He was assigned to Low-A Vermont that season, where he had a.200 batting average in 71 games with the club
He struck out 66 times, compared to only 13 walks.
He only hit 6 home runs, despite the high K/BlackBerry ratio. He still earned a promotion for the next season, 2009, playing with Single-A Hagerstown.
He played in 111 games with a.297 batting average, his highest to date. He struck out an average of once a game, and had 87 Reserve Bank of India. His improved K/BlackBerry ratio earned him a promotion, this time to Double-A Harrisburg.
2010 was his breakout season, playing in 129 games with a.269 average.
He didn"t decrease his K/BlackBerry ratio, but he did hit 31 home runs as a response. He also had 111 Reserve Bank of India and an.873 Office of Personnel Services. He played 2011 with Triple-A Syracuse, where he hit.270 in 137 games. He had 31 home runs again, but his Reserve Bank of India total decreased, and his K/BlackBerry ratio increased.
Moore was added to the Nationals" 40 man roster on November 18, 2011.
On April 29, 2012, Moore was recalled to Washington when Mark DeRosa was placed on the 15-day Doctor of Laws. Moore was hitting.286 with 7 Human Resources and 20 Reserve Bank of India in 22 games with Triple-A Syracuse. On June 13, 2012, during a game against the Toronto Blue Jays, Tyler Moore hit his first two home runs of his Major League career and 5 Reserve Bank of India.