Ulrich Klotz was born on January 15, 1943, in Pirna, Saxony, Germany, to Rudolf Klotz and Elisabeth Olzscha Klotz. Pirna is a historic town on the Elbe in Saxony, a region whose universities and medical institutions became important to the development of modern German science and clinical research after the Second World War.
Klotz studied biochemistry at the University of Tübingen, receiving a master's qualification in 1968. The University of Tübingen, founded in 1477, is one of Germany's oldest universities and has long maintained strong traditions in medicine and the natural sciences.
He received a Doctor of Philosophy in pharmacology from the University of Hannover in 1972. The university's medical and scientific faculties formed part of the postwar expansion of German university research, including experimental pharmacology and the developing discipline of clinical pharmacology. A later record identifies him as a professor at the University of Tübingen from 1984.
Klotz began his research career in 1968 as a research associate in the Department of Pharmacology in Hannover, remaining there until 1972. He then worked as a research associate at Vanderbilt University in Nashville from 1972 to 1973. Vanderbilt, founded in 1873 in Nashville, had developed a major medical and biomedical research environment by the period of Klotz's appointment.
In 1973 he joined the Institute of Clinical Pharmacology at the Robert Bosch Hospital in Stuttgart as a research assistant. The institute, later known as the Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, became associated with research linking pharmacological mechanisms, drug metabolism, pharmacokinetics, and therapeutic decision-making. Klotz served as deputy head from 1980 and continued his work there through at least 2008.
His research addressed the movement and transformation of medicines in the human body, including hepatic elimination, pharmacokinetic variability, drug interactions, and the effects of aging and disease on drug therapy. His publications also examined proton-pump inhibitors, benzodiazepines, gastrointestinal pharmacotherapy, and the bridging role of clinical pharmacology between experimental research and patient care.
Klotz was a visiting scientist at the University of California, San Francisco, in 1982 and served as a consultant to the Bundesgesundheitsamt in Berlin from 1989. UCSF's School of Pharmacy was an important American center for pharmacokinetic and clinical pharmacology research, while the Bundesgesundheitsamt was the former federal public-health authority responsible for scientific and regulatory functions in West Germany before its reorganization in the 1990s. He also held a professorial position at the University of Tübingen from 1984.
Klotz made documented contributions to clinical pharmacology through research on pharmacokinetics, drug metabolism, hepatic elimination, drug interactions, and the effects of aging and disease on medication therapy.
He contributed to the development and dissemination of clinical pharmacology through scientific articles, editorials, professional teaching, and books dealing with pharmacotherapy and pharmacokinetics.
(An article presenting proton-pump-inhibitor pharmacology ...)
2005(A German-language book co-authored by Ulrich Klotz on the...)
2007(A book co-authored by Ulrich Klotz and Devarakonda R. Kri...)
1990(An editorial discussing clinical pharmacology as a bridge...)
2007(A co-authored study examining CYP2E1 activity in patients...)
1997(A review of age-related changes in organ function, drug m...)
2009Klotz was associated with the German Society for Pharmacology and Toxicology, serving as deputy head of its clinical pharmacology section from 1994 to 1997. He was also a member of the American Association for the Study of Liver Diseases and the American Society for Clinical Pharmacology and Therapeutics. These organizations support research, professional exchange, education, and the development of clinical and experimental approaches to medicines and liver disease.
Klotz married Maria Stanke on February 25, 1972. They have two children, Karen and Petra.
