Doctor of Medicine with honors, University Milan, 1977.
Training in neurology University Milan, 1981, training in neurosurgery, 1989, assistant professor neurology, 1981-1988, associate professor, 1989—2001. Research director neurobiology Dino Ferrari Center, 1981—2001. Research director in molecular genetics Institute Sieroterapico Milanese, 1987-1990.
Professor, chairman department neurology University Milan Medical School/Istituto di ricovero e cura a carattere scientifico Institute Auxologico Italiano, since 2002. Director Amystrophic Lateral Sclerosis and Parkinson's Disease Centers, Milan, since 1994, Dino Ferrari Center, University Milan Medical School. Postdoctoral fellow in neurology Baylor College Medicine, Houston, 1979-1980, visiting professor Baylor College Neurology, 1989.
Examiner Italian Medical License, Milan, since 1983, mem steering committee World Federation Neurology, Motor Neuron Disease Subgroup.
Member of American Association for the Advancement of Science, Amyotrophic Lateral Sclerosis /MRD European Consortium (co-chairman since 2003), New York Academy of Sciences, American Academy Neurology, American Society Neuronal Transplantation, Network of European Central Nervous System Transplantation and Restoration (secretary 1991, president 1992, vice president 1993-1994), Italian Neuropathology Association (founder, counselor 1985-1987), Italian Neurosci. Association, Society for Neurosci.
Married Sabine M. Pabisch, March 23, 1991. Children: Francesco M., Margherita M.