Macdonald, Virginia B. was born in 1920 in El Paso, Texas, United States. Daughter of Wendell Holmes and Dorothy (White) Blue.
Student, University New Mexico.
Secretary House Republican Caucus General Assembly, 1972. Member Illinois House Representatives, 1973—1983, Illinois Senate, 1983—1993.
Delaware 6th Illinois Constitutional Convention, 1970. Co-chairman Cook County Republican Center Committee, 1964—1968, Illinois Assembly Council Women. Member advisory committee Wheeling Township Republican Committee.
Chairman Statewide Women's Division Everett McKinley Dirksen's Campaign, 1968. Member advisory council Resource Center Elderly, Community Counciling Center, Suburban Branch Salvation Army. Past president Illinois Federation Republican Women, 1972—1974.
Member of Mount Prospect Business and Professional Women.
Married Alan Hunter MacDonald, 1941. Children: Susan, Susan, Alan H.