Vladimir Mikhailovich served in the Red Army during the Russian Civil War and in 1920 joined the Communist Party, which sent him to the Sverdlov Communist University. As a young idealist, he was upset by the New Economic Policy, and this is reflected in his early plays.
Vladimir Mikhailovich Kirshon was an organizer of the Association of Proletarian Writers in Rostov-on-Don and in the North Caucasus, and from 1925 was one of the secretaries of the Russian Association of Proletarian Writers (RAPP) in Moscow. He was among the most radical literary functionaries of the day, and was one of the most relentless persecutors of Mikhail Bulgakov.
His early plays Konstantin Terekhin (1926) and Rel'sy gudyat (The rails are humming, 1927) "caused a sensation," but Khleb (Bread, 1931) "had but an ephemeral success." His later Chudesny splav (The miraculous alloy, 1934) was still popular in the 1960s.
At the beginning of 1937, however, Vladimir Mikhailovich fell out of favor due to his close association with Leopold Averbakh, former head of RAPP and brother-in-law of Genrikh Yagoda. At a public meeting he was relentlessly attacked by Vsevolod Vishnevsky for associating with an "enemy of the people" and criticizing decisions of the Politburo; he attempted to defend himself, but was expelled from the Party and the Writers' Union and soon disappeared from Moscow. In August 1937 he was arrested along with other former RAPP leaders as Trotsky sympathizers, and the next year he was executed at Butyrka prison in Moscow. Vladimir Mikhailovich was posthumously rehabilitated in 1955 and his plays performed again.